TECHNOLOGY LICENSING OPPORTUNITY: SignalGen
Special Notice from Department of Energy.
Data as of Oct 24, 2026. Sources: SAM.gov and Grants.gov. Snapshot govcon-directory-20261024T104923Z-2151694.
This product uses the Grants.gov API but is not endorsed or certified by the U.S. Department of Health and Human Services. Counts and totals are computed by DSE from public SAM.gov and Grants.gov notices. Text from Grants.gov may be shortened or have contact details removed. The original notice on Grants.gov is the authoritative version.
Closing in 149 days
Notice details
- Agency
- Department of Energy
- Sub-tier agency
- ENERGY, DEPARTMENT OF
- Notice type
- Special Notice
- Solicitation number
- S-195368
- Product/service code
- AN12
- Place of performance
- Los Alamos, New Mexico
- Posted
- Sep 23, 2026
- Response deadline
- Mar 22, 2027
- Source
- SAM.gov
Description
A platform that predicts the right signal peptide for a specific protein Many medicines, vaccines, and biotechnology products rely on proteins reaching the right cellular compartment or secretion outside a cell. Whether a protein gets there in enough quantities depends on its signal peptide or leader sequence. Scientists can identify many existing signal peptides, but predicting which one will work best for a specific protein remains difficult. SignalGen uses generative AI to predict the signal peptide most likely to guide a protein to the right location. To make that prediction, it considers the protein, where it needs to go, and the organism it comes from. This approach gives researchers a new way to improve protein expression for medicines, vaccines, and biotechnology products. Overview: Proteins carry out many of the body's essential functions, but they can only do their job if they reach the right place inside or outside a cell. Many proteins rely on signal peptides to get there. Typically, a signal peptide is a short sequence segment at the beginning of a protein that acts like a built-in address label, helping direct the protein to the location where it is needed. Predicting the right signal peptide for a specific protein remains challenging. Existing software can identify known signal peptides or determine whether a protein already contains one, but it cannot predict which signal peptide is best suited to produce the desired protein expression and cellular location
Summarized from the official notice. The description is shortened; read the full text on the official notice.
Official notice
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When is the response deadline?
The published deadline is Mar 22, 2027. That is 149 days after the data date.
What NAICS code applies?
NAICS 541714, Research and Development in Biotechnology (except Nanobiotechnology).
Which agency issued this notice?
Department of Energy.
Where is the official notice?
The link under Official notice opens the source listing.