Generative Unconstrained Intelligence Drug Engineering (GUIDE) collaboration between U.S. interagency, academic and industry partners
Special Notice from Department of Defense.
Data as of Oct 24, 2026. Sources: SAM.gov and Grants.gov. Snapshot govcon-directory-20261024T104923Z-2151694.
This product uses the Grants.gov API but is not endorsed or certified by the U.S. Department of Health and Human Services. Counts and totals are computed by DSE from public SAM.gov and Grants.gov notices. Text from Grants.gov may be shortened or have contact details removed. The original notice on Grants.gov is the authoritative version.
Closing in 725 days
Notice details
- Agency
- Department of Defense
- Sub-tier agency
- DEPT OF THE ARMY
- Notice type
- Special Notice
- Solicitation number
- W911SR-25-S-GUIDE
- Product/service code
- AC13
- Place of performance
- Frederick, Maryland
- Posted
- Sep 24, 2026
- Response deadline
- Oct 18, 2028
- Source
- SAM.gov
Description
W911SR-25-S-GUIDE Notice Type: Special Announcement Synopsis: This is a solicitation for parties interested in participating in projects sought by the The Joint Project Lead Chemical, Biological, Radiological, and Nuclear Defense Enabling Biotechnologies (JPL-CBRND-EB) (JPL EB). JPL EB has the mission to accelerate the delivery of medical countermeasures to the warfighter through the development and implementation of platform systems. Generative Unconstrained Intelligence Drug Engineering (GUIDE) is an integrated computational and experimental platform designed to accelerate medical countermeasure development. GUIDE harnesses the power of advanced simulation and machine learning to enable preparedness and facilitate rapid response to protect the warfighter from a diverse and dynamic threat space. GUIDE impacts the discovery and design of biological products (e.g., monoclonal antibodies and vaccines) as well as small molecule drugs by simultaneously optimizing critical quality attributes of safety, efficacy, manufacturability and pharmacokinetics/pharmacodynamics while concurrently accounting for critical design attributes affecting developability and biophysical properties. GUIDE is a collaboration between U.S. interagency, academic and industry partners and is closely linked to the Accelerated Antibodies, Rapid Access to Products in Development (RAPID), Vaccine Acceleration by Modular Progression (VAMP), and Rapid Acquisition and Investigation of Drugs for Repurposing
Summarized from the official notice. The description is shortened; read the full text on the official notice.
Official notice
Requirements and amendments are controlled by the official notice.
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See DSE GovCon plans →Prior awards (USAspending)
Department of Defense obligated $14,777,575 under NAICS 541715 on awards whose period of performance started in the last 12 months.
Source: USAspending.gov, U.S. Department of Treasury, Bureau of the Fiscal Service, https://www.usaspending.gov. Accessed Oct 24, 2026. Award totals are computed by DSE from USAspending.gov award data.
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Set up free alerts →Frequently asked questions
When is the response deadline?
The published deadline is Oct 18, 2028. That is 725 days after the data date.
What NAICS code applies?
NAICS 541715, Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology).
Which agency issued this notice?
Department of Defense.
Where is the official notice?
The link under Official notice opens the source listing.